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KMID : 0043320080310070886
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Archives of Pharmacal Research
2008 Volume.31 No. 7 p.886 ~ p.890
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Anti-platelet Effects of Flavonoids and Flavonoid-glycosides from Sophora japonica
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Kim Jeong-Mi
YunChoi Hye-Sook
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Abstract
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A methanol extract of Sophora japonica was subjected to anti-platelet activity guided fractionation affording the isolation of four flavonoids and six flavonoid-glycosides: biochanin A (1), irisolidone (2), genistein (3), sissotrin (4), sophorabioside (5), genistin (6), tectoridin (7), apigenin (8), quercitrin (9), and rutin (10). The structure of each compound was determined by a variety of spectroscopic methods. Among the compounds, 1, 3, and 7 showed fold greater inhibitory effects on arachidonic acid (AA) and U46619 induced platelet aggregation (: 19.9 and ; 20.3 and ; 25.9 and , respectively) than acetylsalicylic acid (ASA, : 63.0 and ). Compound 2 was an fold stronger inhibitor than ASA on AA and U46619 induced aggregation (: 1.6 and , respectively).
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KEYWORD
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Anti-platelet, Flavonoids, Flavonoid-glycosides, Sophora japonica
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